The Data

The Zoonomia Project is comparing genomes of diverse mammals to understanding the basis of remarkable phenotypes, and the origins of disease. In addition to the 131 new assemblies produced, we have generated three types of comparative data.

*Please note that these files are quite large, and will occupy a large amount of computer memory.


To access genome assemblies used in our Zoonomia alignment, please visit the “mammalian tree” and click on your species of interest.


Our 240-species Cactus genome alignment (file format: .hal) was made without reference to any single genome. As a result, it includes both regions shared across eutherian mammals, and regions unique to specific lineages.

Conservation Scores

Conservation scores calculated from the Zoonomia alignment identify sites and regions under purifying selection. With 240 species, we find 3.1% of sites in the human genome to be under purifying selection using PhyloP, with a false discover rate threshold of 5%.

Phylogeny files

Coming soon…

Please click HERE to contact us for up-to-date information on citing Zoonomia in your studies. Thank you for referencing our work!